CYP17 adı verilen bir genin varyasyonu, cinsiyet hormonlarının metobalizmasında rol oynamaktadır ve er anlayış gelişimini etkilemektedir. Bu varyasyon erkeklerde hanımlara için henüz yaygındır. 2008’de Avusturya’da yapılan bir mesafeştırmada, Clemens Tempfer ve meslektaşları kadından erkeğe transseksüellerin %44’ünün, transseksüeloğlu olmayan hanımefendilerin ise %31’inin bu varyasyona ehil bulunduğunu bulmuştur.
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